Photo: Lark L A Coffey

Lark L A Coffey- Ph.D.
Associate Professor
Pathology, Microbiology & Immunology

1 Shields Ave
Davis, CA 95616

+1 530 752 2946
lcoffey@ucdavis.edu

   

Research Focus

Mosquito-borne virus ecology, evolution and emergence

My research seeks to understand patterns of viral molecular evolution and the viral genetic factors that promote mosquito-borne virus emergence and disease.

Specialty Focus

Genetics of mosquito-borne viruses

Transmission dynamics of mosquito-borne viruses

Surveillance of mosquito-borne viruses

Alphaviruses, flaviviruses

RNA virus evolution

Education

2000 B.S. Biology, University of the South, Sewanee, Tennessee
2005 Ph.D. Experimental Pathology, University of Texas Medical Branch, Galveston, Texas
2011 Virology, Institut Pasteur, Paris, France
2013 Virus Discovery, Blood Systems Research Institute/University of California San Francisco, California, San Francisco, California
2018 Arbovirology, University of California, Davis, Davis, California

Honors and Awards

2007-2009 Sigma Xi Scientific Honor Society
2005-2008 Philippe Foundation International Scholar, Institut Pasteur, Paris, France
2005 Zhou Sisters Academic Scholarship, University of Texas Medical Branch, Galveston, TX
2002 Bodhan Nechay Academic Scholarship; University of Texas Medical Branch, Galveston, TX

Licenses

UC Davis Biomedical and Engineering Entrepreneurship Academy Graduate

Active Research Grants

Principal Investigator, Engineering high fidelity mutations to increase safety of live-attenuated alphavirus vaccines , (Principal Investigator), NIH NIAID

Co-Investigator, Characterization of blood transfusion-transmission of Zika virus in macaques, Mike Busch, Blood Systems Research Institute/UCSF (Principal Investigator), NIH NHLBI extension of Recipient Epidemiology and Donor Evaluation Study-III

Co-Investigator, Macaque model of Zika virus infection, Koen Van Rompay (Principal Investigator), NIH NIAID

Co-Investigator, Pacific Southwest Regional Center of Excellence for Vector-Borne Disease Research at the University of California, Chris Barker, PMI, William Walton, UC Riverside (Principal Investigator), Centers for Disease Control Regional Centers of Excellence

Co-Principal Investigator, Chikungunya virus like particle vaccine development: non-human primate studies to establish correlates of protection, Koen Van Rompay, California National Primate Research Center (Principal Investigator), FDA via PaxVax, Inc.

Co-Investigator, Cognitive, affective, and social development following fetal Zika virus infection of rhesus macaques. Percentile: 4, Eliza-Bliss Moreau, UC Davis (Principal Investigator), NIH NICHD

Principal Investigator, Viral molecular determinants of pathogenic mosquito-borne virus emergence: Usutu virus in Europe and St. Louis encephalitis virus in California, (Principal Investigator), Zoetis UCD2

Principal Investigator, Influenza A virus surveillance in avians and marine mammals in California, (Principal Investigator), NIH NIAID Center for Excellence in Influenza Virus Research

Most Recent 10 Publications

  • Lark L A Coffey: An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar 2019 Grubaugh ND, Gangavarapu K, Quick J, Matteson NL, Goes De Jesus J, Main BJ, Tan AL, Paul LM, Brackney DE, Grewal S, Gurfield N, Van Rompay KKA, Isern S, Micahel SF, Coffey LL, Loman NJ, Andersen KG. An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar Genome Biology,
  • Lark L A Coffey: Chikungunya virus fidelity variants exhibit differential attenuation and population diversity in cell culture and adult mice 2019 Riemersma KK, Steiner, Singapuri A, Coffey LL Chikungunya virus fidelity variants exhibit differential attenuation and population diversity in cell culture and adult mice Journal of Virology,
  • Lark L A Coffey: A Combination of Two Human Monoclonal Antibodies
Prevents Zika Virus Escape Mutations in Non-human
Primates 2018 Keeffe JR, Van Rompay KKA, Olsen P, Wang Q Gazumyan A, Azzopardi SA, Schaefer-Babajew D, Lee YE, Stuart JB, Singapuri A, Watanabe J, Usachenko J, Ardeshir A, Saeed M, Agudelo M, Eisenreich T, Bournazos S, Oliveira TY, Rice CM, Coffey LL, MacDonald MM, Bjorkman PJ, Nussenzweig MC, Robbiani, DF A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates Cell Reports,
  • Lark L A Coffey: St. Louis encephalitis virus in the Americas: emergence, persistence, and re-emergence of a mosquito-borne flavivirus 2018 Diaz A, Coffey LL, Burkett-Cadena N, Day JF St. Louis encephalitis virus in the Americas: emergence, persistence, and re-emergence of a mosquito-borne flavivirus Emerging Infectious Diseases,
  • Lark L A Coffey: Virome of ~20,000 Culex mosquitoes collected throughout California 2018 Sadeghi M, Altan E, Deng X, Barker C , Fang Y, Coffey LL, Delwart E Virome of ~20,000 Culex mosquitoes collected throughout California Virology,
  • Lark L A Coffey: Scented sugar baits enhance detection of St. Louis encephalitis and West Nile viruses in mosquitoes in suburban California 2018 Steiner CD, Riemersma KK, Stuart JB, Singapuri A, Lothrop HD, Coffey LL Scented sugar baits enhance detection of St. Louis encephalitis and West Nile viruses in mosquitoes in suburban California J Med Entomol doi.org/10.1093/jme/tjy064,
  • Lark L A Coffey: Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates 2018 Dudley DM, Van Rompay KK , Coffey LL, Ardeshir A, Keesler RI, Bliss-Moreau E, Grigsby PL, Steinbach RJ, Hirsch AJ, MacAllister RP, Pecoraro HL, Colgin LM, Hodge T, Streblow DN, Tardif S, Patterson JL, Tamhankar M, Seferovic M, Aagaard KM, Sánchez-San Martín C, Chiu CY, Panganiban AT, Veazey RS, Wang X, Maness NJ, Gilbert MH, Bohm RP, Adams Waldorf KM, Gale Jr. M, Rajagopal L, Hotchkiss CE, Mohr EL, Capuano III SV, Simmons HA, Mejia A, Friedrich TC, Golos TG, O’Connor DH Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates Nat Med,
  • Lark L A Coffey: Vector competence of Aedes aegypti, Culex tarsalis, and Culex quinquefasciatus from California for Zika virus 2018 Main BJ, Nicholson J, Winokur OC, Steiner C, Riemersma KK, Stuart J, Takeshita R, Krasnec M, Barker CM, Coffey LL Vector competence of Aedes aegypti, Culex tarsalis, and Culex quinquefasciatus from California for Zika virus PLoS Negl Trop Dis,
  • Lark L A Coffey: Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease 2018 Coffey LL, Keesler RI, Pesavento PP, Woolard K, Singapuri A, Watanabe J, Cruzen C, Christe KL, Usachenko JU, Yee J, Heng VA, Bliss-Moreau E, Reader JR, von Morgenland W, Gibbons AM, Jackson K, Ardeshir A, Heimsath H, Permar SR, Senthamaraikannan P, Presicce P, Kallapur SG, Linnen JM, Gao K, Orr R, MacGill T, McClure M, McFarland R, Morrison JM, Van Rompay KKA. Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease Nat Commun,
  • Lark L A Coffey: New genotypes of Liao ning virus (LNV) in Australia exhibit an insect-specific phenotype 2018 Prow NA, Mah MG, Deerain JM, Warrilow D, Colmant AMG, O'Brien CA, Harrison JJ, McLean BJ, Hewlett EK, Piyasena TBH, Hall-Mendelin S, van den Hurk AF, Watterson D, Huang B, Schulz BL, Webb CE, Johansen CA, Chow WK, Hobson-Peters J, Cazier C, Coffey LL, Faddy HM, Suhrbier A, Bielefeldt-Ohmann H, Hall RA New genotypes of Liao ning virus (LNV) in Australia exhibit an insect-specific phenotype J Gen Virol,

Most Recent 5 Book Chapters

2016 Coffey L: The Nature of Viruses, MacLachlan, NJ, Dubai, EJ, (ed), Fenner’s Veterinary Virology, London. 13-16.

2016 Coffey LL, Weaver SC, Forrester N: Alphavirus Evolution, , Alphaviruses: Molecular Biology, Pathogenesis and Host Interactions. 21-26.

2016 Forrester NL, Gutierrez S, Coffey LL: The Evolution and Transmission of Vector-Borne Viruses, Weaver, Denison, Roossinck, Vignuzzi, (ed), Virus Evolution: Current Research and Future Directions. 61-100.

2015 Tsetsarkin K, Coffey LL, Weaver SC: Interaction of Chikungunya virus with the mosquito vector, , Chikungunya Virus. 99-126.

2008 Coffey LL: Togaviruses not associated with human disease, Mahy B, Van Regenmortel M, (ed), Encyclopedia of Virology, 3rd Edition, Oxford. 91-6.

External Links

Lab Website